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KMID : 0383820060610050447
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Tuberculosis and Respiratory Diseases
2006 Volume.61 No. 5 p.447 ~ p.455
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The Expression of MMPs and TIMPs in IPF and NSIP
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Kim Yu-Jin
Kim Jung-Ho
Jeon Hyo-Keun
Kim Mi-Kyeong
Jo Young-Chan
Kyung Sun-Yong
An Chang-Hyeok
Lee Sang-Pyo
Park Jung-Woong
Ha Seung-Yeon
Jeong Sung-Hwan
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Abstract
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Background: MMPs and TIMPs are important factors for abnormal remodeling the pulmonary parenchyme in idiopathic interstitial pneumonia(IIP) This study evaluated the expression of MMPs and TIMPs in the tissue of IPF, NSIP and normal control subjects.
Method: The MMP-2 and -9 activity in the lung tissue was studied by gelatin zymography, and the expression of MMP-1, -2 ,-9, TIMP-1 and -2 in the lung tissue was measured by immunohistochemistry. Thirty five patients, who were diagnosed with IIP (UIP ; 22, NSIP ; 13), were enrolled in the immunohistochemical study. Thirteen patients with IIP (UIP ; 9, NSIP ; 4) and five patients with lung cancer were enrolled in the zymographic assay.
Results: (1) The immunohistochemistry for MMP-1,-2,-9, TIMP-1 and-2 ; MMP-1,-9 and TIMP-2 were stained stronger in the UIP subjects than NSIP and the normal control. TIMP-2 was strongly stained in the UIP tissue. particularly the fibroblasts in the fibroblastic foci. (2) Zymography for MMP-2 and MMP-9 revealed MMP-2 to have prominent expression in the UIP tissue than in the NSIP tissue.
Conclusions: These results suggest that the overexpression of the TIMPs and gelatinases in UIP might be important factors in the irreversible fibrosis of the lung parenchyme (Tuberc Respir Dis 2006; 61: 447-455)
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KEYWORD
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IIP, MMPs, TIMPs
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